The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations
نویسندگان
چکیده
منابع مشابه
The tandem duplicator phenotype as a distinct genomic configuration in cancer.
Next-generation sequencing studies have revealed genome-wide structural variation patterns in cancer, such as chromothripsis and chromoplexy, that do not engage a single discernable driver mutation, and whose clinical relevance is unclear. We devised a robust genomic metric able to identify cancers with a chromotype called tandem duplicator phenotype (TDP) characterized by frequent and distribu...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2018
ISSN: 1535-6108
DOI: 10.1016/j.ccell.2018.06.008